NTI generics require specialized bridging studies to ensure safety, with tighter bioequivalence limits and complex designs. Learn why these drugs are harder to make, how regulators ensure quality, and what it means for patients.
NTI medications like warfarin, lithium, and digoxin have a tiny margin between safe and toxic doses. Expired versions can lose potency or degrade unpredictably, risking life-threatening complications. Never use them past their expiration date.
Digoxin generics may be bioequivalent on paper, but individual absorption varies - making therapeutic drug monitoring essential to avoid toxicity or treatment failure in heart patients.