Wellbutrin (bupropion): what it does and what to watch for
Wellbutrin is the brand name for bupropion, an antidepressant often used for major depressive disorder and to help people stop smoking. It works differently from SSRIs — it boosts dopamine and norepinephrine — so it can help when SSRIs cause tiredness, weight gain, or sexual side effects. Many people notice more energy and clearer focus, but it’s not right for everyone.
How Wellbutrin works & when doctors prescribe it
Doctors commonly prescribe Wellbutrin for depression and as Zyban for smoking cessation. It comes in three main forms: immediate-release (IR), sustained-release (SR), and extended-release (XL). Typical starting doses are 150 mg once daily (XL) or 150 mg twice daily (SR). The usual maximum is 300–450 mg per day depending on formulation. Your prescriber will pick the form and dose based on symptoms, other meds, and your medical history.
People who switched to bupropion often report less sexual dysfunction than on SSRIs and sometimes weight loss. It can also help with low motivation and fatigue. That said, it takes a few weeks to work and you should keep regular follow-ups so your doctor can adjust the dose if needed.
Safety, side effects & buying tips
Common side effects include dry mouth, trouble sleeping, headache, sweating, and jitteriness. A key safety issue is seizure risk — bupropion can increase seizures, especially above 450 mg/day, or in people with eating disorders, heavy alcohol use, or seizure history. Don’t take it if you have bulimia or uncontrolled alcohol withdrawal. Also avoid combining it with MAOIs or using it within 14 days of stopping an MAOI.
Watch for mood changes, worsening depression, or suicidal thoughts, especially in people under 25. Check your blood pressure occasionally — bupropion can raise it in some people. If you’re pregnant or breastfeeding, discuss risks and benefits with your clinician; many providers will consider alternatives or monitor closely.
If you’re buying Wellbutrin online, only use pharmacies that require a prescription and show clear credentials. Look for US state licensing, pharmacist contact info, and third-party seals like NABP or LegitScript when available. Avoid sites that sell without a prescription or offer suspiciously low prices with no paperwork. Use price comparison tools or discount cards to save money, but don’t skip the prescription — quality and safety matter with psych meds.
Stopping bupropion usually doesn’t require a long taper for most people, but follow your doctor’s plan. If side effects are severe or you experience a seizure or new mood problems, stop and seek urgent care. With the right follow-up and a reliable pharmacy, Wellbutrin can be a helpful option when other meds don’t fit. Talk openly with your prescriber about goals, side effects, and any worries about buying meds online so you get safe, effective care.
