Darunavir is a powerful HIV protease inhibitor used to keep viral levels low and protect the immune system.
Doctors give it alongside a boosting agent (ritonavir or cobicistat) and other antiretrovirals. You usually take darunavir with food to improve absorption. This simple step makes a big difference in how well the drug works.
How darunavir works and who should take it
Darunavir blocks the HIV protease enzyme, stopping the virus from making mature infectious copies. Clinicians prescribe it for people starting treatment and for those who need a stronger option because of resistance. Your doctor will pick doses based on prior treatment and other medicines you take.
Common dose and practical tips. The common dose for adults is 800 mg of darunavir once daily with 100 mg ritonavir or 150 mg cobicistat, taken with a meal. For some people with resistance, doctors may split the dose to 600 mg twice daily with ritonavir. Always follow the exact regimen your clinician gives you — don’t change timing or skip doses. Missing doses raises the risk of resistance.
Side effects and what to watch for. Minor side effects include nausea, diarrhea, and headache. Some people notice increased cholesterol or blood sugar. Less common but serious problems include liver inflammation and severe rash. If you see jaundice, dark urine, high fever with rash, or sudden breathing trouble, get medical help right away.
Drug interactions to avoid. Darunavir interacts with many drugs because it affects liver enzymes, especially CYP3A. Avoid St. John’s Wort and strong enzyme inducers. Certain heart, blood thinner, and psychiatric drugs may need dose changes or substitution. Always tell your doctor and pharmacist every medication, supplement, or herb you use.
Monitoring and tests. Expect regular checks of viral load and CD4 count to see if treatment controls the virus. Your clinician may monitor liver tests, blood sugar, and lipids, especially when starting therapy. Drug level tests are not routine but may be used in complex cases.
Pregnancy, breastfeeding, and special situations. Pregnant people should discuss darunavir with their care team; it can be used during pregnancy but dosing and boosters may need attention. Breastfeeding is generally not recommended for people with HIV in settings where safe alternatives exist. Pediatric dosing and adjustments for kidney or liver disease require specialist input.
Buying darunavir online — safety tips
Only use licensed pharmacies and always get a prescription. Avoid sites that sell prescription drugs without verifying a prescriber. Cheap pills with unclear origins risk treatment failure and harm. If you must order online, check for pharmacy accreditation, clear contact details, and a requirement for a valid prescription.
Quick practical reminders. Take darunavir with food, keep a strict schedule, report new symptoms quickly, and never stop treatment without medical advice. If you worry about side effects or interactions, ask your clinic pharmacist—they can often suggest safe alternatives or monitoring plans.
For more readable guides and safe buying tips, search the darunavir tag on 247-healthstore.com or talk to your care team for free support any time online.
